Dr Stephen John Middleton MA MD FRCP FAHE

Consultant Gastroenterologist

Peer Reviewed Publications

Percutaneous balloon valve dilatation (1989). S J Middleton British Medical   Journal 6;   298(6682): 1251
Haemorrhagic pancreatitis: A cause of death in severe potassium permanganate poisoning. 
S J Middleton, M Jacyna, R Robinson and H C Thomas. Postgrad    
 Med J 1990; 66: 657-658
Endoscopic and histological findings in subjects with and without dyspepsia. (1991). S J Middleton, J O Hunter. 
British Medical Journal    302:   1083.
Impending paradoxical embolism, a rare but important diagnosis c M E Speechly-Dic, S J Middleton,
R A Foale. Br Heart J 1991; 65 (3): 1163-5.
The role of faecal Candida albicans in the pathogenesis of food intolerant irritable bowel syndrome.  
S J Middleton, A Coley, J O Hunter. Postgrad Med J 1992; 68:453-454
99Tcm and 111In leucocyte scintigraphy in inflammatory bowel disease. D J Li., S J Middleton,
E P Wraight. Nuclear Medicine Communications 1992; 13: 867-870.
Relaxation of distal colonic circular smooth muscle by nitric oxide derived from  human leucocytes. 
S J Middleton, M Shorthouse, J O Hunter.
Gut  1993; 34: 814-817
Nitric oxide affects mammalian distal colonic circular smooth muscle by tonic neural inhibition. 
 S J Middleton, A W Cuthbert, M Shorthouse, J O Hunter. 
B J Pharmacol 1993; 108: 974-979.
Increased nitric oxide synthesis in ulcerative colitis. 
S J Middleton, M Shorthouse, J O  Hunter.
 Lancet 1993;341: 465-466
Therapeutic aspects of nutrition in Crohn's disease. 
S J Middleton, J O Hunter.
Journal of the Irish Colleges of Physicians and Surgeons 1995; 24(1).
Nitric Oxide in Ulcerative Colitis.
P D Reynolds, S J Middleton, G M Hansford, J O Hunter.
Lancet 1995; 345: 448.
Long chain triglycerides reduce the efficacy of enteral feeds in patients with active Crohn's disease.
S J Middleton, J T Rucker, G A Kirby, A M Riordan, J O Hunter. Hunter. 
Clinical Nutrition 1995; 14: 229-236.
Nitric oxide synthesis in gastric mucosa. 
S J Middleton, ,P D Reynolds, M Shorthouse, J O Hunter, S Moss. 
Gut 1995; 36(6): 942
Validation of 99Tcm-HMPAO leucocyte scintigraphy in ulcertive colitis by comparison with histology.
S J Middleton, D Li, S Wharton, P D Reynolds, E P Wraight, J O Hunter. 
Br J Radiology 1995; 68: 1061-1066
The effects of aminosalicylic acid derivatives on nitric oxide in a cell free system.
 P D Reynolds, S J Middleton, M Shorthouse, J O Hunter. 
Alimentary Pharmacology & Therapeutics 1995; 9: 491-95
Increased nitric oxide synthesis in ulcerative colitis. 
S J Middleton, J O Hunter. Inflammatory Bowel Diseases

(G N J Tytgat, J F W M Bartelsman, S J H Van Deventer, eds). 
Kluwer Academic Publishers, Dordrecht. pp.101-105
N-3 Polyunsaturated fatty acids in the treatment of inflammatory bowel disease.
J O Hunter, J T Woolner, S J Middleton.
Proceedings of the Falk Symposium No. 96, held in Freiburg, Germany October 30 - Nov 1 1996.
Confirmation of nitric oxide synthesis in active ulcerative colitis by infra-red diodelaser  spectroscopy.
P D Reynolds, S J Middleton, G M Hansford, J O   Hunter.
European Journal of Gastroenterology and Hepatology 1997; 9: 463-466.
Multiple frequency bioimpedance: a bed-side technique for assessment of fluid shift patterns in a patient
with severe dehydration. O Dewit, L Ward, S J Middleton, C Watson, P J Friend, M Elia. 
Clinical Nutrition 1997; 16: 189-192
Intestinal transplantation between two identical triplets.
R Y Calne, P J Friend, S Middleton, N V Jamieson,C J E Watson, A Soin, R Chavez-Cartaya.
Lancet 1997  Oct.11;350(9084):1077-8
Distribution of glutaminase and glutamine synthetase activities in the human gastrointestinal tract.
 L A James, P G Lunn, SMiddleton, M Elia. 
Clinical Science 1998: 94: 313-319
Quantitation of DNA from Exfoliated Colonocytes isolated from Human Stool surface as a Novel
Non invasive Screening test for Coloectal Cancer.
A Lotkionov, I K O’Neill, K R Silvester, J Cummings, S J Middleton and R Miller. 
Clinical Cancer Research 1998; 4: 337-342
Glutamine oxidation and utilization by rat and human oesophagus and duodenum.
 L A James, P G Lunn, S J Middleton, M Elia.

Br Journal of Nutrition 1999; 81; 323-329
Paroxysmal nocturnal haemoglobinuria mimicking Crohn’s disease. S Sivakumaran, J O Hunter ,
S Middleton. GUT 1999; 44: 889
Small intestine transplantation from cadaver donors: procurement procedure. R Chavez-Cartaya,
NV Jamieson, PJ Friend, S Middleton, RY Calne. Transplant  proc 1999; 31(6): 2565-6
Intestinal Transplantation: 1997 Report of the International Registry. D Grant of  behalf of the 
 Intestinal Transplant Registry.Transplantation 1999 Vol. 67, 1061-1064, No. 7
Treatment of oesophageal Crohn's disease by Enteral feeding via percutaneous endoscopic gastrostomy.
T Thomas, E Berto, M Scribano, S J Middleton, J O Hunter.
Journal of  Parenteral and Enteral Nutrition 2000, Vol.24, No.3
Management of Acute Diarrhoea. EAB Cameron, SJ Middleton.
CPD Journal Internal Medicine  2000, Vo1.1 No.3
Evaluation of the effectiveness of a specialist nurse in the management of inflammatory bowel disease (IBD).
A Nightingale, W Middleton, SJ Middleton, JO  Hunter.
European Journal of Gastroenterology & Hepataology 2000, 12:1 - 7
Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease.
P  J Roberts, K Morgan, R Miller, JO Hunter SJ Middleton.
GUT 2001; 48: 468-472
The physiological expression of inducible nitric oxide synthase (Inos) in the human colon. 
PJ   Roberts, GP Riley, K Morgan R Miller, JO Hunter, SJ Middleton. 
Journal of Clinical  Pathology 2001; 54: No 4: 293-297
Parenteral nutrition and small bowel transplantation as treatments for irreversible intestinal failure in adults.
EAB Cameron, JAH Binnie, SJ Middleton.
TTMed-Gastroenterology. August  2001.
A family history study of chronic fatique syndrome.
G M Walsh, N Z Sainal, S J Middleton, E S Paykel.
Psychiatric Genetics 2001. 11:No:3
3 year prospective validation of a pre-endoscopic risk stratification in patients with acu upper GI haemorrahage.
EAB Cameron, JN Pratap, TJ Sims, S Inman, D Boyd, M Ward, SJ Middleton.
Euro.Journal of Gastroenterology & Hepatology 2002; 14: No5.
Quality of life in adults following small bowel transplantation.
EAB Cameron, JAH Binnie, Jamieson, S Pollard SJ Middleton.
Transplantation Proceedings. 2002; 34, 000.
Rofecoxib and cytomegalovirus in acute flare up of ulcerative colitis: Co-precipitants or co incidence?
 J Goh, D Wight, M Parkes, SJ Middleton, JO Hunter.
American Journal of Gastroenterology. 2002 Apr;97 (4):1061-2.
Expression of isoforms of nitric oxide synthase in collagenous colitis.
EAB Cameron, S J Middleton.

GUT 2002; 50(6).
A double blind-randomised placebo-controlled trial of essential fatty acid supplementation in maintenance of
remission in ulcerative colitis. SJ Middleton, S Naylor, J Woolner, JO Hunter.
Alimentary Pharmacology & Therapeutics. 2002; 16: 1131-1135.
Efficacy and safety of renzapride in patients with constipation-predominant irritable bowel  syndrome.
NL Meyers, J Tack, S Middleton, M Horne, H Piessevaux, JR Bloor and RMJ Palmer.
GUT 2002; 51: S3, A10.
Irritable bowel syndrome. Stephen Middleton. Primary Health Care,
2002; 12: No10 1  December   2002.
The Significance of Low-Grade Uptake in Tc-99m HMPAO-WBC Imaging for  Inflammatory  Bowel Disease.
K Balan, C Beadsmoore, A Groves, C Solanki, S Middleton, A Freeman. World Journal of Nuclear
Medicine. 2003; 2:92-95.
Elemental diet in the treatment of orofacial Crohn’s disease. EAB Cameron, SJ Middleton. 
GUT. 2003; Vol.52 1:143.
Adult small intestinal transplantation in England and Wales. 
SJ Middleton, S Pollard, PJ 
Friend, C Watson, RY Calne, M Davies, EA Cameron, AE Gimson, JA Bradley, 
J Shaffer, NV Jamieson. 
British Journal of Surgery. 2003; 90: 723-727.
Oral prednisolone metasulphobenzoate in the treatment of active ulcerative colitis Predocol  i
n Ulcerative Colitis. 
EAB Cameron, JAH Binnie, K Balan, SA Skerratt, A Swift, C Solanki, SJ Middleton. 
Scand J Gastroenterol.2003; 5:535-537.
Relapsing encephalopathy following small bowel transplantation. 
SM Shah, PJRoberts, 
CJE Watson, PJ Friend, NV Jamieson, RY Calne, SJ Middleton. 
Transplant Proceedings. Transplantation Proceedings 35, 156-1566 (2003).
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 
1 deficiency. 
RS Jackson, JWM Creemers, IS Farooqi, ML Rffin-Sanson, a Varro, GJ Dockray, JJ Holst, PL Brubaker, 
P Corvol, KS Polonsky, D Ostreta, KL Becker, Z Bertagna, JC Hutton, A White, MT Dattani, K Hussain, 
SJ Middleton, TM Nicole, PJ Milla, KJ Lindley and S O’Rahilly. 
The Journal of Clinical Investigation. 2003; Vol 112 No10.
Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates 
(orginal research article. GH Williams, R Swinn, AT Provost, P de Clive-Lowe, I Halsall, JJ Going, CN Hales, 
K Stoeber and SJ Middleton. 
Brtitish Journal of Cancer. (2004) 91, 714-719.
Quantification of disease acvtivity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease. Middleton SJ, Peters AM.
Eur J Nucl Mol imaging. 2004 Cheow etal,
The current status of small intestinal transplantation in the UK and internationally. 
S J Middleton and N V Jamieson. 2005
Gut (54): 1650-1657
Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation 
predominant IBS. 2006 J Tack, SJ Middleton, MC Horne, H Piessevauvs, JS Bloor, NL Meyers, RMJ Palmer.
Is intestinal transplantation now an alternative to parenteral nutrition for patients with intestinal failure ? 
Proc Nutr Soc. 2007 Aug;66(3):316-20. Review
Cambridge-Miami score for properative risk assessment : initial developmnt and validation
Middleton, Nishida, Tzakis, Woodward, Duncan, Watson, Wiles, Sivaprakasam, Butler, Gabe, Jamieson.
Transpant proceedings 2010 42(1):19-21
Utility of whole gut transit scintigraphy in patients with chronic gastrointestinal symptoms.
Balan K, Alwis L, Sonoda LI, Pawaroo D, Parry-Jones DR, Middleton S.
Nucl Med Commun. 2010 Apr;31(4):328-33.
 Clinical significance of scintigraphic rapid gastric emptying.
Balan K, Sonoda LI, Seshadri N, Solanki C, Middleton S.
Nucl Med Commun. 2011 Dec;32(12):1185-9.
 Post-prandial reactive hypoglycaemia and diarrhea caused by idiopathic accelerated gastric emptying: a case report.
Middleton SJ, Balan K.
J Med Case Rep. 2011 May 13;5:177
 Idiopathic accelerated gastric emptying presenting in adults with post-prandial diarrhea and reactive hypoglycemia: a case series.
Middleton SJ, Balan K.
J Med Case Rep. 2012 May 19;6(1):132
Intestinal transplantation : Review article for Medicine series – the latest developments. Medicine,2012 (39):3; 183-190
Case Report: Multidrug-Resistant Cytomegalovirus in a Modified Multivisceral Transplant Recipient.
Petra M. Goldsmith; Mir Mubariz Husain; Andrew Carmichael; Hongyi Zhang; Stephen J.Middleton. Transplantation April 15, 2012, Volume 93, Issue 7
Vedolizumab as induction and maintenance therapy for Crohn's disease. GEMINI 2 Study Group. N Engl J Med. 2013 Aug 22;369(8):711-21.
Preoperative comorbidity correlates inversely with survival after intestinal and multivisceral transplantation in adults.
Sivaprakasam R, Hidenori T, Pither C, Nishida S, Butler AJ, Island ER, Moon J, Dawwas M, Gab e SM, Jamieson NV, Tzakis AG, Middleton SJ.J Transplant. 2013;2013:202410
Use of the alpha glucosidase inhibitor acarbose in patients with 'Middleton syndrome': normal gastric anatomy but with accelerated gastric emptying causing postprandial reactive hypoglycemia and diarrhea.
Playford RJ, Pither C, Gao R, Middleton SJ
Can J Gastroenterol. 2013 Jul;27(7):403-4.
Panaccione R, Ghosh S, Middleton S, Márquez JR, Scott BB, Flint L, van Hoogstraten HJ, Chen AC, Zheng H, Danese S, Rutgeerts P.
Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis.Gastroenterology. 2013 Oct 25. pii: S0016-5085(13)01526-6
Preoperative comorbidity correlates inversely with survival after intestinal and multivisceral transplantation in adults.
Sivaprakasam R, Hidenori T, Pither C, Nishida S, Butler AJ, Island ER, Moon J, Dawwas M, Gabe SM, Jamieson NV, Tzakis AG, Middleton SJ.
J Transplant. 2013;2013:202410
Delayed dynamic abdominal wall closure following multi-visceral transplantation.
Iype S, Butler A, Jamieson N, Middleton S, Jah A.
Int J Surg Case Rep. 2014;5(12):988-91. doi: 10.1016/j.ijscr.2014.08.006. Epub 2014 Oct 13.
Psychiatric disorders in patients undergoing intestinal transplantation.
Pither C, Green J, Butler A, Chukaulim B, West S, Gao R, Gabe S, Middleton SJ.
Transplant Proc. 2014 Jul-Aug;46(6):2136-9.
Prothrombotic disorders in a cohort of 25 patients undergoing transplantation: investigation and management implications.
Pither C, Middleton S, Gao R, Sharkey L, Jamieson N, Butler A.

Transplant Proc. 2014 Jul-Aug;46(6):2133-5.
Adult small intestinal and multivisceral transplantation: lessons through the "retrospecto-scope" at a single UK centre from 1991 to 2013.
Middleton SJ, Pither C, Gao R, Duncan S, Green J, Sharkey L, Chukualim B, Kratzing C, Woodward J, Gabe SM, Jamieson N, Butler A.
Transplant Proc. 2014 Jul-Aug;46(6):2109-13

Quality of life and performance status before and after small intestinal transplantation.
Pither C, Duncan S, Gao R, Butler A, West S, Gabe SM,
Middleton SJ.
Transplant Proc. 2014 Jul-Aug;46(6):2114-8
Urgent Multivisceral Transplantation for Widespread Splanchnic Ischemia.
Sharkey LM, Russell NK, Rutter CS, Middleton SJ, Bradley JA, Jamieson NV, Butler AJ. J Am Coll Surg. 2016 May;222(5):760-5.
Adult Intestinal and Multivisceral Transplantation: Experience From a Single Center in the United Kingdom. Rutter CS, Amin I, Russell NK, Sharkey LM, Butler AJ,
Middleton SJ. Transplant Proc. 2016 Mar;48(2):468-72.

Stomal Cytomegalovirus Infection Following Intestinal Transplant.
Ambrose T, Sharkey L,Louis-Auguste J, Butler A, Massey D, Russell N, Pursglove S,
Middleton SJ. Am J Gastroenterol. 2015 Nov;110(11):1534.


Cytomegalovirus Infection and Rates of Antiviral Resistance Following Intestinal and Multivisceral Transplantation.
Ambrose T, Sharkey LM, Louis-Auguste J, Rutter CS, Duncan S, English S,
Gkrania- Klotsas E, Carmichael A, Woodward JM, Russell N, Massey D, Butler A,
Middleton S. Transplant Proc. 2016 Mar;48(2):492-6.

Stacks Image 296